You can't live without NAD+.
The bad news: NAD+ levels are destroyed by aging, inflammation, diet, stress, and sickness. This leads to weakness, frailty, and even faster aging.
The good news: You can help restore your NAD+ levels with exercise, nutrition, and targeted supplement formulas.
NAD+ precursor response is personal.
The enzymes that rebuild your NAD+ stores vary by person and tissue, so the same supplement doesn’t always produce the same effect.
Supporting multiple pathways with NMN, NR, and Trigonelline helps you get reliable, steady NAD+ support without guesswork.
NAD+ boosters like NMN and NR are only the beginning.
After years of analyzing the research, we've aligned with a systems-level approach to address four main pathways to support healthy NAD+ levels throughout the entire body. This systems-level approach is described elegantly by Nichola Conlon and Dianne Ford in a recent study on NAD+ restoration.
Every Renue By Science formula helps you maximize NAD+ through one of these pathways.
Boost
Protect
Optimize
Regenerate
You’re too young to feel this tired.
Remember when you could stay up until 2 AM and still crush it the next day? When hangovers lasted hours, not days? When you could stay focused without that afternoon espresso?
The resilience and energy of youth comes from NAD+.
By age 50, you have half the NAD+ you had at 20. As you celebrate more birthdays, that decline continues further.¹
You don't have to accept this as "normal aging" when you look at it as a solvable problem.
Is it just aging, or are your NAD+ pathways slowing down?
When one pathway stalls, your energy suffers.
NAD+ is essential for energy, repair, and resilience. As we age, NAD+ synthesis pathways slow down, leading to a dramatic drop in cellular energy. By age 50, we have half of what we did when we were younger. Factors like poor diet, sedentary lifestyles, illness, and environmental toxins deplete NAD+ even faster.
Our scientifically designed multi-pathway formulas restore NAD+ where your biology needs it most.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. If you ran out, your body would stop working – within seconds. It fuels the enzymes responsible for DNA repair, energy production, cellular stress response, and gene expression. Without it, your cells can’t function, adapt, or repair themselves.
As you age, your NAD+ levels drop up to 50% by age 50, and even more in tissues under metabolic stress. This decline isn’t just a side effect of aging: it’s a driver of it.
Collapsible content
Boost (Build the NAD+pool)
Boost (Build the NAD+pool)
What it targets: Low cellular NAD+.
How it works: Supplies precursors that feed the body’s NAD+-making routes so more raw NAD+ is available when cells need it.
Includes: NMN, NR, Trigonelline, and direct NAD+.
Why it matters: A higher, steadier supply supports daytime energy metabolism and cell maintenance.
Protect (Guard what you make)
Protect (Guard what you make)
What it targets: Unnecessary NAD+ drain from inflammatory signaling and overactive NAD+-consuming enzymes.
How it works: Senolytic and polyphenol support helps lower senescent-cell burden and modulates enzymes like CD38 and PARPs, conserving NAD+ for useful work.
Includes: Fisetin, Quercetin, Apigenin, Hesperidin.
Why it matters: Less waste means more NAD+ available for repair, resilience, and metabolism.
Optimize (Use NAD+efficiently)
Optimize (Use NAD+efficiently)
What it targets: Sluggish mitochondrial output and metabolic inflexibility.
How it works: Activates cellular switches (AMPK, SIRT1/3) and supports electron transport so cells convert fuel to ATP more cleanly.
Includes: Resveratrol, Berberine, EGCG, CoQ10, CaAKG.
Why it matters: Better utilization turns a steady NAD+ pool into steady energy and recovery.
Regenerate (Nighttime renewal)
Regenerate (Nighttime renewal)
What it targets: Buildup of worn-out components and poor overnight recovery.
How it works: Encourages autophagy/mitophagy and calm sleep architecture so cells can recycle and rebuild while you rest.
Includes: Spermidine, GABA, 5-HTP, Apigenin.
Why it matters: Cleaning and rebuilding at night sets up stronger NAD+ dynamics the next day.
What is NAD+ and why should you care?
Think of NAD+ (nicotinamide adenine dinucleotide) as your cellular fuel and repair crew rolled into one.
Every cell in your body uses NAD+ to:
Turn food into energy. Without it, your mitochondria can't make ATP.²
Repair DNA damage that happens 70,000 times per day.³
Activate longevity genes called sirtuins that keep cells strong.⁴
Clean out cellular garbage like damaged proteins and dying mitochondria.⁵
Evidence for the four-pathway approach.
We analyzed hundreds studies and found:
- Multiple precursors work better:Different cells prefer different NAD+ builders.
- CD38 is the hidden problem: It increases with age, eating your NAD+.
- Mitochondria need support: Better efficiency = less NAD+ waste.
- Sleep is when repair happens: Poor sleep = higher NAD+ demand.
Key Studies:
NMN improves insulin sensitivity (Science, 2021)
Quercetin inhibits CD38 (Diabetes, 2013)
Resveratrol enhances mitochondria (Cell Metabolism, 2011)
Spermidine activates autophagy (Nature Medicine, 2016)
Taking NMN or NR alone is like filling a bucket with holes in it. Sure, you're adding NAD+to your system by taking a precursor, but you're not addressing the enzymes like CD38 literally eating your NAD+faster than you can make it, the inflammation driving those enzymes higher, the inefficient mitochondria wasting what NAD+you do have, or the cellular damage creating constant NAD+demand.
Individual responses vary widely to NAD precursor supplementation.
While some people feel great from taking NMN, others may feel a small difference or nothing at all. This is why the 4 pathway approach works: we account for individual variation in precursor response so you can experience the benefits of boosting yourNAD+levels without having to guess which form will work best for you.
This graph shows the NMN Group (red triangles) overall had higher NAD+ levels compared to the Placebo Group (blue circles) at weeks 4 and 12.However, individual responses varied (red triangles show a range from 25 to 90 µM).
The cellular energy crisis.
Why Modern Life Destroys NAD+:
Blue light exposure disrupts circadian .NAD+.
Processed foods are inflammatory and increase CD38.
Chronic stress means constant repair demand.
Sedentary lifestyle damages mitochondrial function.
Poor sleep shortens or eliminates nightly recovery window.
Alcohol detoxification depletes NAD+ stores.
The mismatch: Your body expects feast/famine cycles, sunrise/sunset rhythms, and physical demands. Instead, it gets constant food, artificial light, and Netflix.The solution: Since we can't live like our ancestors, we need to supplement what modern life depletes.
Fatigue and poor recovery
NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.
NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.
Brain fog and forgetfulness
NAD+ powers neuron firing and synaptic connections. Low NAD+ means slower thinking, poor focus, and that frustrating word-on-the-tip-of-your-tongue feeling.
NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.
Weaker immunity
NAD+ powers immune cell activation and inflammatory balance. Low NAD+ means longer recovery from illness and increased susceptibility to infections.
NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.
Slower repair and regeneration
NAD+ powers DNA repair and cellular regeneration. Low NAD+ means injuries heal slowly, skin ages faster, and recovery takes longer.
NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.
The functional cost of NAD+ loss.
YOU MAY NOT SEENAD+LEVELS DECLINE, BUT YOU CAN FEEL THE CONSEQUENCES.
Liposomal delivery means greater bioavailability.
Liposomal delivery wraps sensitive ingredients like NMN and NR in phospholipids, the same fats that make up cell membranes, so they’re protected during digestion and first-pass liver processing.
This translates to more of the active ingredients reaching your cells where you need them most, and more powerful effects at significantly lower doses.
Our Team
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Bryan Nettles-Founder and CEO
Nutrition and exercise have been a primary focus for me throughout my life. My passion is in science and research, especially as it relates to healthy aging.
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Dr. Rebecca Crews-Research Director
Dr. Rebecca Crews is the Research Director at Renue by Science, leading the company’s engagement in transformative research.
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Dr. Clark Driggers-Chief Medical Advisor
Dr. Clark Driggers, serves as the Chief Medical Advisor at Renue By Science, specializing in wellness, anti-aging, and regenerative medicine.
FAQ’s
Where are your products manufactured?
Where are your products manufactured?
All Renue By Science products are manufactured in cGMP-certified facilities in the United States. We partner with manufacturers who exceed basic GMP standards to ensure the highest quality production. Our manufacturers maintain strict quality controls throughout the entire production process, from raw material sourcing to final bottling.
What quality standards do your products meet?
What quality standards do your products meet?
Quality and safety are our top priorities. Our products are manufactured in cGMP-certified facilities which exceed industry standards. The cGMP certification guarantees the most current and rigorous quality controls. Every batch undergoes third-party testing to verify purity, potency, and conformity to label claims.
Where do you source your NMN from?
Where do you source your NMN from?
Our raw NMN is sourced from select suppliers in China, which is a common practice in the vitamin and supplement industry. While we have previously worked with multiple vendors, we currently source exclusively from Effepharm because of their consistent reliability and quality. That said, we maintain relationships with other suppliers to ensure an uninterrupted supply of NMN when needed.
How do you ensure product quality?
How do you ensure product quality?
Safety and purity are our top priorities, and we have implemented rigorous testing procedures that exceed industry standards. Our process includes: 1) Initial testing of raw ingredients upon receipt in the United States. 2) Processing and refinement in FDA-registered facilities. 3) Comprehensive testing of each batch of finished product.We are committed to full transparency in our quality control process. We are the only brand in the industry to publish detailed test results for every batch of finished product on our website. Each product is labeled with a batch number which allows customers to verify the test results for their purchase.
What sets Renue By Science apart in terms of manufacturing?
What sets Renue By Science apart in terms of manufacturing?
All processing, testing, and packaging occur in FDA-registered facilities in the United States. This approach ensures that our products meet the highest standards of quality and safety. By adhering to these stringent practices, we provide our customers with supplements of the highest quality and reliability. Our commitment to transparency, quality assurance, and manufacturing in the US sets us apart in the industry.
Are your products vegan?
Are your products vegan?
Yes. All of our products are vegan, except for our Skin & Body Essentials Powder which contains grass-fed bovine collagen.